3 May 2016

Health Highlights: 2016


Here are some of the latest health and medical news developments, compiled by the editors of HealthDay:

Huge Price Increases for Oral Cancer Drugs Since 2000: Study

Prices of oral cancer drugs in the United States have risen sharply since 2000, a new study finds.

The average cost of a new oral cancer drug introduced in 2000 was about $1,869 a month, compared with $11,325 a month for one approved in 2014, about six times higher, United Press International reported.

Gleevec had one of the largest price increases during that time, rising about 7.5 percent a year and increasing from $3,346 to $8,479 a month, according to the University of North Carolina researchers.

The study was published in the journal JAMA Oncology.

The researchers said the skyrocketing prices have occurred along with health insurance changes making patients bear more of the cost, and potentially making treatment unaffordable for some, UPI reported.

Posted: May 2016

High School Football Players Suffer More Symptoms After Concussion

High School Football Players Suffer More Symptoms After Concussion: Study


High school football players are more likely to suffer more symptoms after a concussion, and to need more recovery time than their college counterparts, a new study finds.
But those who play in youth football leagues are the most likely to get back on the field less than 24 hours after a concussion, the researchers discovered.

"The finding related to return-to-play under 24 hours being the highest in the youth level is surprising, but may be the result of young football players struggling to identify concussion symptoms and express how they feel [to coaches or trainers]," explained lead researcher Zachary Kerr, from the Datalys Center for Sports Injury Research and Prevention, in Indianapolis.

With mounting evidence suggesting that concussions that happen earlier in life have a cumulative effect on the developing brain, finding ways to better spot and treat these serious head injuries in younger players is more pressing than ever.

For the study, Kerr and his colleagues analyzed data from three injury programs. They found that more than 1,400 sports-related concussions were reported among youth, high school and college football players from 2012 to 2014. The most common symptoms reported were headache, dizziness and difficulty concentrating.

Overall, about 15 percent of players did not return to play for at least 30 days after a concussion, while 3 percent returned to play less than 24 hours after being injured, the researchers found.

The study found that high school football players had the highest average number of reported symptoms of concussion (5.60), followed by college athletes (5.56) and younger players (4.76).

For high school players, the likelihood of returning to play at least 30 days after concussion was higher (19.5 percent) than younger players (just over 16 percent), or college football players (7 percent), the researchers found.

The researchers suggested biological factors, such as puberty and brain development, may explain the differences in recovery time among the age groups.

Meanwhile, the youngest players were the most likely to return to play less than 24 hours after suffering a concussion (10 percent), followed by college (close to 5 percent) and high school players (just under 1 percent), Kerr added.

It's vital to educate young football players about concussions, as well as parents, coaches and officials on recognition and management of these head injuries, Kerr said. "Appropriate medical care includes managing and returning players to the game at the appropriate time," he said.

Most colleges have an athletic trainer on the field during football games and practices to help spot and treat injuries, Kerr said. "However, a number of high schools do not have access to a full-time athletic trainer, and many youth football leagues do not have any access. An investment in an athletic trainer at these games and practices is an investment in the health and safety of our adolescent and children athletes," he said.

The study findings were published online May 2 in the journal JAMA Pediatrics.

About 3 million young kids, 1 million high school students and 100,000 college athletes play football each year, the researchers said. Sports-related concussions, which can cause emotional, mental and sleep-related symptoms, are gaining more attention among players, coaches and parents, the researchers added.

Many factors influence how concussions are managed at different age levels, said Dr. John Kuluz, director of traumatic brain injury and neurorehabilitation at Nicklaus Children's Hospital in Miami.
For example, "college coaches are all over these kids in terms of monitoring, treating and taking them out of class and seeing that they rest," he said.

High school and middle school is a different story, where "it's a chore trying to get these kids accommodations to recover from a concussion," Kuluz said.

High school teachers have academic demands and players are often reluctant to admit they have symptoms, he added.

"Some kids are high achievers. They don't want any accommodations. They want to play so badly they don't admit to having symptoms," Kuluz explained.

"In many cases, high school students are ridiculed or not believed when they report symptoms of a concussion," he said. "I see that all the time."

High schools have to allow these athletes time to recover, Kuluz said.
Luckily, students are becoming savvier, he added: "My hope is that athletes are going to get even smarter about concussions. It's all up to the athletes reporting the symptoms."

More information
For more information on concussion, visit the American Association of Neurological Surgeons.

Chemo-related Memory Issues And Talk Therapy


Could Talk Therapy Ease Chemo-Related Memory Issues?


A type of psychotherapy might help cancer survivors deal with the long-term thinking problems some experience after chemotherapy, researchers say.

It's estimated that about half of those who undergo chemotherapy for cancer develop what's often called "chemo brain." For instance, they may have trouble following conversations or remembering the steps in a project, according to background notes with the new study.

Although usually mild, these changes can affect quality of life, job performance and relationships, said the researchers from the Eastern Maine Medical Center and Lafayette Family Cancer Center in Bangor, Maine.

The researchers developed a cognitive-behavioral therapy (CBT) program called Memory and Attention Adaptation Training to help cancer survivors prevent or manage these memory problems.

Their study involved 47 breast cancer survivors who underwent chemotherapy an average of four years earlier. Some were assigned to receive eight CBT sessions that lasted about 30 to 45 minutes each.

The rest received supportive talk therapy sessions.

For both groups, the sessions were conducted via videoconference to minimize patients' travel time. Participants also completed thinking tests and answered questionnaires about their memory issues and related anxiety. Verbal memory and processing speed was also tested.

Participants were retested after completing all eight sessions and again two months later.

The CBT participants reported significantly fewer memory problems and better processing speed than those who received supportive therapy, according to the study published online May 2 in the journal CANCER. They also reported much less anxiety about mental problems two months after their psychotherapy ended.

"This is what we believe is the first randomized study with an active control condition that demonstrates improvement in cognitive symptoms in breast cancer survivors with long-term memory complaints," said study leader Robert Ferguson in a journal news release. He is currently at the
University of Pittsburgh Cancer Institute.

"Participants reported reduced anxiety and high satisfaction with this cognitive-behavioral, non-drug approach," Ferguson said. Also, because treatment was delivered via videoconference device, he said the study demonstrates it's possible "to improve access to survivorship care."


More information
The National Alliance on Mental Illness provides more information on cognitive-behavioral therapy.

FDA Approves New Drug For Parkinson’s Disease Psychosis

FDA Approves Nuplazid

 

 

FDA Approves Nuplazid (pimavanserin) for Parkinson’s Disease Psychosis
April 29, 2016 -- The U.S. Food and Drug Administration today approved Nuplazid (pimavanserin) tablets, the first drug approved to treat hallucinations and delusions associated with psychosis experienced by some people with Parkinson’s disease.
Hallucinations or delusions can occur in as many as 50 percent of patients with Parkinson’s disease at some time during the course of their illness. People who experience them see or hear things that are not there (hallucinations) and/or have false beliefs (delusions). The hallucinations and delusions experienced with Parkinson’s disease are serious symptoms, and can lead to thinking and emotions that are so impaired that the people experiencing them may not relate to loved ones well or take appropriate care of themselves.
“Hallucinations and delusions can be profoundly disturbing and disabling,” said Mitchell Mathis, M.D., director of the Division of Psychiatry Products in the FDA’s Center for Drug Evaluation and Research. “Nuplazid represents an important treatment for people with Parkinson’s disease who experience these symptoms.”
An estimated 50,000 Americans are diagnosed with Parkinson’s disease each year, according to the National Institutes of Health, and about one million Americans have the condition. The neurological disorder typically occurs in people over age 60, when cells in the brain that produce a chemical called dopamine become impaired or die. Dopamine helps transmit signals between the areas of the brain that produce smooth, purposeful movement -- like eating, writing and shaving. Early symptoms of the disease are subtle and occur gradually. In some people Parkinson’s disease progresses more quickly than in others. As the disease progresses, the shaking, or tremor, which affects the majority of people with Parkinson’s disease, may begin to interfere with daily activities. Other symptoms may include depression and other emotional changes; hallucinations and delusions; difficulty in swallowing, chewing, and speaking; urinary problems or constipation; skin problems; and sleep disruptions.
The effectiveness of Nuplazid was shown in a six-week clinical trial of 199 participants. Nuplazid was shown to be superior to placebo in decreasing the frequency and/or severity of hallucinations and delusions without worsening the primary motor symptoms of Parkinson’s disease.
As with other atypical antipsychotic drugs, Nuplazid has a Boxed Warning alerting health care professionals about an increased risk of death associated with the use of these drugs to treat older people with dementia-related psychosis. No drug in this class is approved to treat patients with dementia-related psychosis.
In clinical trials, the most common side effects reported by participants taking Nuplazid were: swelling, usually of the ankles, legs, and feet due to the accumulation of excessive fluid in the tissue (peripheral edema); nausea; and abnormal state of mind (confused state).
Nuplazid was granted breakthrough therapy designation for the treatment of hallucinations and delusions associated with Parkinson’s disease. Breakthrough therapy designation is a program designed to expedite the development and review of drugs that are intended to treat a serious condition and where preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over available therapy on a clinically significant endpoint. The drug was also granted a priority review. The FDA’s priority review program provides for an expedited review of drugs that offer a significant improvement in the safety or effectiveness for the treatment, prevention, or diagnosis of a serious condition.
Nuplazid is marketed by Acadia Pharmaceuticals Inc. of San Diego, California.
Source: FDA
Posted: April 2016

Related Articles:

Nuplazid (pimavanserin) FDA Approval History

FDA Alert: Drug Safety Communication

Brintellix (vortioxetine): Drug Safety Communication - Brand Name Change to Trintellix, to Avoid Confusion With Antiplatelet Drug Brilinta (ticagrelor)

May 3, 2016
Audience: Psychiatry, Internal Medicine, Pharmacy

ISSUE:
FDA has approved a brand name change for the antidepressant Brintellix (vortioxetine) to decrease the risk of prescribing and dispensing errors resulting from name confusion with the blood-thinning medicine Brilinta (ticagrelor). The new brand name of the drug will be Trintellix, and it is expected to be available starting in June 2016. No other changes will be made to the label or packaging, and the medicine is exactly the same.

Because of the lag time associated with manufacturing bottles with the new brand name, health care professionals and patients may continue to see bottles labeled with the brand name Brintellix during the transition period.

In a July 2015 MedWatch Alert, FDA warned that name confusion between Brintellix and Brilinta had resulted in prescribing and dispensing errors since Brintellix was approved in September 2013. Due to continued reports of name confusion between the two medicines used for very different purposes, FDA worked with Brintellix manufacturer Takeda Pharmaceuticals to change the drug’s brand name.


BACKGROUND:
Brintellix/Trintellix (vortioxetine) is used to treat a certain type of depression called major depressive disorder in adults. It is in a class of antidepressants called serotonin reuptake inhibitors (SSRIs) that work by affecting chemicals in the brain that may become unbalanced.


RECOMMENDATION:

Health care professionals should check carefully to make sure they have prescribed or dispensed the correct medicine. During the transition to the new name change from Brintellix to Trintellix, prescribers can reduce the risk of name confusion by including the generic name of the medication they are ordering, in addition to the brand name and indication for use. Patients should make sure they have received the correct medicine. Trintellix tablets will look the same as the Brintellix tablets. Those having any questions or concerns should talk to their prescriber or pharmacist.

Individuals responsible for ordering and stocking the medicine should be aware that Trintellix will have a new National Drug Code (NDC) number. It is important for drug information content publishers and medication-related electronic system administrators to use the new brand name Trintellix and NDC number once Takeda makes vortioxetine available under the new name Trintellix.

Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program:
  • Complete and submit the report Online: www.fda.gov/MedWatch/report
  • Download form or call 1-800-332-1088 to request a reporting form, then complete and return to the address on the pre-addressed form, or submit by fax to 1-800-FDA-0178
[05/02/2016 - Drug Safety Communication - FDA]

2 May 2016

I Love You

I Love You



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     data-ad-format="auto">



You look at me as if I'm the only girl around
You make me feel important and never let me down


You've shown me how to live
How to smile, what to say



You've shown me what it's worth
To love someone each and every day


So this poem goes out to you
For everything you've done


And I hope now you understand
That baby, you're the one!

I Love You, Baby!


- Shannon -

German Frankfurt School Bachelor and Master Degree Scholarships

 
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Top ranking universities are offering full scholarships for international students. With so many to choose from, it's not always easy finding the right one. We help you understand what's what and show you how you can study abroad. If you need help then please email at help@scholarship-positions.com.


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